The greatest martial arts is invincible with speed; these doctors really didn't expect the professor to act so quickly, without any warm-up, mobilization, or precursor actions, but directly getting started.

After listening to the professor's introduction, Jiang Jitong timely said, "Professor, regarding the design of enhancer proteins, can we adopt a strategy of functional domain jigsaw? By extracting specific receptor-binding domains from known protein structures with immunoregulatory functions, such as TLR ligand recognition domain, transmembrane domain or internalization signal domain, and co-stimulatory signal domain, and connecting them with a reasonable flexible linker, to construct a multifunctional chimeric protein? Then use tools like AlphaFold2 for preliminary screening and verify the function through in vitro experiments?"

The four new doctors immediately turned their attention to him; the senior brother was somewhat whimsical, such an immature suggestion should not be spoken in this occasion.

They thought, if their previous mentors heard such whimsical talk, they would surely scold him head-on: Use your brain, can't you? Say something practical.

At this time, everyone couldn't help but worry if Senior Brother Jiang would get scolded.

However, Professor Yang looked at him approvingly and nodded, "Your suggestion is very good. It's difficult to achieve, but if it weren't difficult, would it still be called a project? Would it still need so many smart heads to spend so much money on full-time research? Everything starts with thinking and then doing; only by thinking first and trying can one have results."

"Just like building complex models with LEGO bricks, we need to screen out the best combination of functional domains, linker length, and order. Liu Yang!" Professor Yang looked at the molecular technology expert, "Protein gene sequence design, codon optimization, plasmid vector construction, and mutant library establishment are your main responsibilities. You need to set up an efficient and rapid molecular cloning platform."

Liu Yang immediately straightened his back and replied in a loud voice, "Understood, Professor! I guarantee to complete the task!"

Though he said that, Liu Yang's mind was a blank about how to actually do it. But he steadied himself, hadn't the professor said? If it was clear and straightforward, would it still be a frontier project? That would be copying homework.

"Chu Xiaoxiao and He Zijian," Yang Ping's gaze turned to the two newcomers with an immunology background, "You will assist Liu Yang in the initial stage, suggesting enhancer protein functional domain selection and design from the perspective of immunological function needs, such as which co-stimulatory signals are most crucial from the T cell activation perspective; Wang Chao, consider how to promote cross-presentation from the perspective of viral antigen presentation. In the mid-to-late stage, you need to establish corresponding functional verification models."

"Yes, Professor!" Chu Xiaoxiao, He Zijian, and Wang Chao spoke in unison, feeling the burden on their shoulders becoming more concrete.

"Chu Xiaoxiao," Yang Ping looked at the girl studying autoimmunity, "Your task is crucial, responsible for enhancing protein's in vitro immunological function verification and high-throughput screening. Once Liu Yang and the team construct and express candidate proteins, you need to quickly establish activation detection models based on human or mouse dendritic cells and macrophages, assessing these proteins' effects on APC surface co-stimulatory molecule expression, cytokine secretion, antigen phagocytosis, and processing capability. Additionally, you must establish preliminary safety assessment models to detect if they induce unwanted cytokine storms or autoimmune tendencies."

Chu Xiaoxiao took a deep breath and nodded firmly, "I understand, Professor! I will set up these platforms as soon as possible." She realized that her work directly correlated with the fate of candidate molecules, bearing a significant responsibility.

She really didn't expect that upon arriving here, she would immediately start with significant tasks. In her impression, such research was usually undertaken by scholars of substantial weight, like Outstanding Young Talent, and she only did specific work.

Constructing? Such a high-profile task, how could it be her turn, she really didn't react in time, but her mouth was faster than her brain, and she already spoke out.

"Professor, your memory is really good, remembering our names all at once." Chu Xiaoxiao suddenly blurted out.

Yang Ping was stunned, this little girl, I can't even remember a few names, is my intelligence so low?

Chu Xiaoxiao giggled, being the only girl in the project group, she was destined to be a favorite in the future.

"As for the connective bridge technology," Yang Ping's gaze finally landed on Jiang Jitong, "Dr. Jiang, this area is your responsibility. Currently, there are several mainstream approaches, such as gene fusion expression, biotin-avidin system, various short peptide tag pairing systems, and chemical conjugation methods. You are responsible for thoroughly researching the advantages and disadvantages, cost, efficiency, and specificity of existing technologies, combining the characteristics of our enhancers and different antigen types, proposing several most feasible technical routes, and conducting preliminary validation experiments. Wang Chao," he once again called on Wang Chao, "Your virology background will help in understanding the structural characteristics and surface modifiable sites of viral antigens. You will assist Dr. Jiang, focusing on evaluating the potential impact of different connection methods on viral antigen conformation and immunogenicity. In short, everyone has their tasks but must cooperate with each other, playing to strengths and avoiding weaknesses; tasks are distinct, but must not be isolated from each other."

"No problem, Professor! I will immediately start literature research and plan design." Jiang Jitong responded decisively, showing his determination not to let down the mission.

Wang Chao also immediately said, "I will fully cooperate with Dr. Jiang's work."

Everyone gradually got into the state, and the initial timidity considerably diminished.

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